Gene expression changes after blockade of Frizzled7 in murine intestinal organoids

RNA was isolated from intestinal primary mouse organoids at 6h and 24h after treatment with dFz7-21 peptide, Fz7-21S (mock) peptide and DMSO. These two time points were specifically selected to investigate early and late transcriptional responses after Fzd7 inhibition. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech''s ExpressionPlot database is PRJ0010717 Overall design: Gene expression profiling of intestinal primary mouse organoids treated with dFz7-21 - a small molecule peptide that specifically and potently blocks Frizzled 7