A Formal Synthesis of the C1−C9 Fragment of Amphidinolide C Employing the Tamaru Reaction
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https://figshare.com/articles/dataset/A_Formal_Synthesis_of_the_C1_C9_Fragment_of_Amphidinolide_C_Employing_the_Tamaru_Reaction/2756182
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资源简介：
Homoallylation of aldehydes with isoprene and triethylborane catalyzed by Ni(acac)2 gave hydroxyalkenes in good yield with excellent regio- and stereoselectivity. Cross metathesis of the hydroxyalkenes with methyl acrylate using second-generation Grubbs catalyst and copper(I) iodide afforded α,β-unsaturated esters, which underwent cyclization in the presence of DBU to produce tetrahydrofurans with the correct relative configuration for the C1−C9 fragment of amphidinolides C, C2, and F.
创建时间：
2010-07-02
