PharmacotherapyDB 1.0: the open catalog of drug therapies for disease

This is the initial release of the PharmacotherapyDB, a catalog of drug therapies for disease. The catalog contains physician curated medical indications.This release contains 97 diseases and 601 drugs. Between these drug–disease pairs, there are 755 disease-modifying therapies, 390 symptomatic therapies, and 243 non-indications. To enable integrative analyses, drugs and diseases are coded using DrugBank and Disease Ontology identifiers.Indications were classified by physician curators into three categories:DM -- disease modifyingSYM -- symptomaticNOT -- non-indicationThis deposition contains the following files:indications.tsv contains drug–disease pairs and their consensus category (DM, SYM, or NOT). n_curators refers to how many of the three curators initially assigned the consensus classification. n_resources refers to how many of the four resources (MEDI-HPS, LabeledIn, EHRLink, PREDICT) included the indication.diseases.tsv contains a list of diseases with indications. For each disease, the number of indications per category is provided.drugs.tsv contains a list of drugs with indications. For each drug, the number of indications per category is provided.catalog.xlsx is a spreadsheet with four sheets:indications — data from indications.tsvdiseases — data from diseases.tsvdrugs — data from drugs.tsvcuration — the classifications from each of the three physician curators (AJG, CSH, & PK).The catalog is released as CC0 1.0. However, please consider that the catalog includes DrugBank and DIsease Ontology identifiers and reference their licenses when appropriate.