Two Co(II)-based coordination polymers: structural diversity and treatment activity on chronic primary glomerulonephritis by reducing ROS accumulation and inflammatory response in glomerular epithelial cells

Two new three-dimensional (3 D) cobalt-based coordination polymers [Co(L)(5-hypa)]n (1, H2hypa = 5-hydroxyisophthalic acid), and [Co(L)(1,4-NDC)]n (2, 1,4-H2NDC = naphthalene-1,4-dicarboxylic acid) have been successfully prepared by using the 3,6-bis(N-imidazolyl) pyridazine (L) and different carboxylate ligands as co-linkers. In the biological study, the treatment effect of compounds 1 and 2 on CPGN was evaluated in vivo and in vitro. After the construction of the CPGN animal model, compounds 1 and 2 were given for treatment. The relative expression of the TGFβ and 1Smad in the glomerular epithelial cells was measured by RT-PCR. The ROS accumulation in the glomerular epithelial cells was detected by ROS detection kit.