Prevalence of Potential Therapeutic Competition in Common Co-existing ChronicConditions among Community-living Persons in the U.S. Aged 65 and Older (N = 5815).

Abbreviations: GERD/PUD, gastroesophageal reflux disease or peptic ulcer disease.aThe most common pairs of coexisting chronic conditions listed in Table 1 for which there is at least one medication (listed in Table 1) recommended by the national specialty organization guidelines that may worsen the other condition in the pair (see Methods for how these competing medications were identified). Of the guideline recommended medications, only prescription medications used by at least 2% of the study sample are included.bEstimated number of persons in U.S. with the competing chronic conditions.cPercent of participants with the coexisting conditions who use the potentially competing medication, that is, a medication recommended for one chronic condition that may worsen the coexisting chronic condition. See Methods for selection criteria for competing medications.dCoronary artery disease includes history of myocardial infarction, acute coronary syndrome, or angina.eManifestations of diabetic autonomic neuropathy, such as orthostasis, may be worsened by alpha/beta-blockers.fProton pump inhibitors use is likely underestimated because nonprescription use of proton pump inhibitors not included in the dataset.