Divergent Synthesis of Functionalized Quinolines from Aniline and Two Distinct Amino Acids

A practicable
quinoline synthesis from aniline and two amino acids
was developed for generating a wide range of quinolines with high
efficiency and diversity. Thus, it facilitated the creations of pharmaceutical
derivatives, photochemical active compounds, and challenging scaffolds.
The concept of using two amino acids as heterocyclic precursors has
been raised for the first time. Mechanistic studies revealed that
I2 enabled decarboxylation, oxidative deamination, and
selective reconstruction of new C–N and C–C bonds processes.