Mismatch repair protein MLH1 suppresses replicative stress in BRCA2 deficient breast tumors

To investigate the cooperative function KDM4D/NFIB/MLL1 complex in the regulation of Mirin Pretreatment, we established 10T1/2 cell lines in which each target gene has been knocked down by shRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points. Overall design: Comparative gene expression profiling analysis of RNA-seq data for mESC cells and its KD derivatives (shKDM4D, shNFIB, and shMLL1).