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Transcriptional effect of CBFA2T3::GLIS2 oncogenic fusion engineering by CRISPR-Cas9 in iPSC-derived hematopoietic cells

ChEBI2025-07-09 更新2026-07-12 收录

基因编辑造血干细胞

致癌融合基因转录组学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-14188 数据链接链接失效反馈

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资源简介：

Transcriptional effect of CBFA2T3::GLIS2 oncogenic fusion engineering by CRISPR-Cas9 in iPSC-derived hematopoietic cells

应用场景：

创建时间：

2025-07-09

基因编辑造血干细胞

p53 DNA损伤响应

We evaluated transcriptional changes elicited by targeting AAVS1 and IL2RG genes and we found that the impact of one or few nuclease-induced DNA DSBs is minor and mainly limited to genes belonging to

NIAID Data Ecosystem110

Additional file 7 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

基因组安全港筛选

基因编辑造血干细胞

Additional file 7: Table S6. GFP flow cytometry data of day 1 and day 90 for WT and GFP inserted HUDEP2 clones.

Figshare2022-09-21 更新60

Clonal Tracking Uncovers Barriers and Validate New Strategies to Enhance Gene Editing in Human Hematopoietic Stem Cells [RNA-seq]

基因编辑造血干细胞

CRISPR-Cas9HDR优化

By applying a barcoding strategy to clonal tracking of edited cells (BAR-seq), we show that p53 activation triggered by HDR editing significantly shrink the HSPC clonal repertoire in hematochimeric mi

NIAID Data Ecosystem50

Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response. Precise Gene Editing Preserves Hematopoietic Stem Cell Function Following Transient p53-Mediate DNA Damage Response

基因编辑造血干细胞

p53DNA损伤应答

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem70

Senescence and inflammation are unintended consequences of CRISPR-Cas9 gene-editing in hematopoietic stem cells [WES]. undefined

基因编辑造血干细胞

基因治疗安全性

Gene editing (GE) in hematopoietic stem and progenitor cells (HSPCs) represents a promising strategy for site-specific gene correction of several inherited diseases. However, its clinical translation

NIAID Data Ecosystem50

Transcriptional effect of CBFA2T3::GLIS2 oncogenic fusion engineering by CRISPR-Cas9 in iPSC-derived hematopoietic cells

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