Transcriptome analysis of cortical excitatory neurons of juvenile brain in wild-type and Nipbl mutant mice

During postnatal development of mammalian brain, neuronal circuits are rewired by experience especially in juvenile stage. This project aims to clarify excitatory neuron-specific transcriptome in the cerebral cortex of juvenile mouse. In addition, the role of Nipbl, which is mutated in Cornelia de Lange syndrome including mental retardation, in the regulation of gene expression in excitatory neurons is examined.