E2A regulates neural ectoderm fate specification in human embryonic stem cells

NIAID Data Ecosystem2026-03-11 收录

神经外胚层分化

胚胎细胞命运决定

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154625 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2020-07-20

p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification

胚胎细胞命运决定

白细胞粘附调控

E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and a

NIAID Data Ecosystem70

Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3

胚胎细胞命运决定

代谢信号调控

Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental pr

NIAID Data Ecosystem20

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene

神经外胚层分化

组蛋白甲基化调控

Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial p

NIAID Data Ecosystem20

Genome-wide maps of chromatin state during the differentiation of hESC into hNECs (MNase-Seq). Homo sapiens

表观遗传调控

神经外胚层分化

To study the epigenetic regulation during neuroectoderm specification process, we generated in-depth maps of nucleosome and histone modifications.We found that the depletion of nucleosome marked with

NIAID Data Ecosystem30

Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions

胚胎细胞命运决定

TGFβ信号传导调控

Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic develop

Figshare2016-01-18 更新20

E2A regulates neural ectoderm fate specification in human embryonic stem cells

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