Different gene expression profiles of granulosa cells in Chinese obese patients with or without polycystic ovary syndrome

Obese or polycystic ovary syndrome (PCOS) women have encountered poor reproductive outcomes in natural as well as assisted conception. Furthermore, pregnancy complications of women with PCOS are profoundly worsened by obesity. Both obesity and PCOS affect function of granulosa cells, which is essential in offering the oocyte with nutrients and growth regulators. Sixteen patients who had undergone in vitro fertility (IVF) or intracytoplasmic sperm injection (ICSI) were enrolled in the study: 8 obese patients—4 none-PCOS(NPO) and 4 PCOS (PO); 8 normal weight patients—4 none-PCOS(NPN) and 4 PCOS (PN). Seven binary comparisons were as follows: (i) NPO/NPN, (ii)PO/PN, (iii) O/N, (iv) PN/NPN, (v) PO/NPO, (vi)P/NP,(vii) PO/NPN.