The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the Comprehensive In Vitro
N=4 male conscious telemetered Cynomolgus monkeys, dosed with astemizole at 3, 10 and 30 mg/kg ? successively per os. No PK phase. Haemodynamic parameters (SAP, DAP, MAP, HR). Lead II ECG (RR, PR, QRS
equil_gating_4_assembly_xleap.prmtop: file topology of the hERG closed state with gating charge 4 equilibration trajectory equil_gating_6_assembly_xleap.prmtop: file topology of the hERG closed state
The version V2.1 is the last update of raw data of the ERBC telemetry database in beagle dogs This new version is is accrued from 22 reference compounds including 15 herg blockers. The list of referen
Gaining understanding of common complex diseases and their treatments are the main drivers for life sciences. As we show here, comprehensive protein set analyses offer new opportunities to decipher fu