Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor

Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor Descriptor: (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Edmondson, S.D, Weber, A.E. Deposit date: 2008-01-29 Release date: 2008-04-22 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 18, 2008

人类二肽基肽酶IV/CD26（Human dipeptidyl peptidase IV/CD26）与氟烯烃抑制剂结合的复合物。配体组成：(2S,3S)-3-{3-[2-氯-4-(甲磺酰基)苯基]-1,2,4-噁二唑-5-基}-1-环亚戊基-4-环丙基-1-氟丁-2-胺、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖……作者：斯卡平（Scapin, G）、埃德蒙森（Edmondson, S.D）、韦伯（Weber, A.E.）。沉积日期：2008-01-29；发布日期：2008-04-22；最后修改日期：2024-10-30。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.05埃。引用文献：《Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors》，发表于《Bioorg.Med.Chem.Lett.》，2008年，第18卷。