BRCA1-specific machine learning model predicts variant pathogenicity with high accuracy - Supplementary material

Figure S1: Distribution of the reviewed 141 <em>BRCA1</em> missense variants; Figure S2: The Shapely values for the <em>BRCA1</em> XGBoost models; Figure S3: The Shapely values of the <em>BRCA1</em> XGBoost model used to predict the functional assays’ results for variants of uncertain significance; Table S1: The receiver operating characteristic (ROC) curve analysis for the different in silico predictions; Table S2: Cross validation of the BRCA1 model in 5 different random training and test samples; Table S3: Pathogenicity prediction and prioritization of the 31,058 unreviewed BRCA1 variants from the BRCA Exchange database.