Compare the effects of opioid-free anesthesia and opiate-based anesthesia on the postoperative pain, anxiety and depression, sleep quality, early postoperative recovery quality and the incidence of postoperative adverse events in patients with colorectal cancer surgery

Interventions: OFA group :Opioid free anethesia ;OBA group:Traditional anethesia Primary outcome(s): NRS pain score;QoR-15;Postoperative adverse reactions associated with opioid use;Anxiety and depression score;PSQI;Cortisol;Adrenalin;Noradrenaline;TNF-a;IL-6;IL-10;MAP;HR;MMP-7;TIMP-1 Study Design: Parallel