Transcriptome of lung epithelial cells stimulated by hemozoin. Transcriptome of lung epithelial cells stimulated by hemozoin

We assessed the transcriptome of epithelial cells exposed to hemozoin, using a combination of robust quantitative transcript modeling and informatics-based network analyses. Results revealed a transcriptional program induced by hemozoin that comprised numerous pro-inflammatory and epithelial- and extracellular matrix-associated genes. Overall design: Examination of response to in vitro stimulation of airway epithelial cells for 24 h with hemozoin at three different concentrations