Jiang et al Sesamol manuscript.xlsx

ExPEC (extraintestinal pathogenic <i>Escherichia coli</i>) represents a significant zoonotic threat when found outside the gut, leading to severe infections and potential cross-host transmission. The ongoing challenge of antibiotic resistance has created difficulties in treating clinical bacterial infections, underscoring the need to develop innovative strategies. It is crucial to create new methods for combating bacterial infections. Host-directed therapy (HDT) utilizing host-acting antibacterial compounds (HAC) has emerged as an effective strategy by focusing on host-pathogen interactions and bacterial survival tactics to address bacterial challenges. In this study, we conducted a cell-based screen to identify compounds capable of inhibiting ExPEC survival and proliferation in host cells.