A Conformationally Arrested Peptidomimetic Antibiotic Disrupts Selectively the Outer Membrane in Escherichia coli
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://www.omicsdi.org/dataset/pride/PXD002588
下载链接
链接失效反馈官方服务：
资源简介：
Using a shotgun proteomics approach, the expressed proteome of total membrane fractions of Escherichia coli ATCC25922 cells was analyzed under i) normal growth, and ii) treatment with the novel peptidomimetic JB-95 (a structurally arrested cyclic peptide). By selectively disrupturing the outer membrane (OM), this peptidomimetic displayed a novel mechanism of action and opens new avenues for developing antibiotics that specifically target the OM of Gram-negative bacteria.
创建时间：
2015-12-07
