Palladium-Catalyzed Fluoroalkylative Cyclization of Olefins

A palladium-catalyzed fluoroalkylative
cyclization of olefins with
readily available Rf–I reagents to afford the corresponding
fluoroalkylated 2,3-dihydrobenzofuran and indolin derivatives with
moderate to excellent yields is reported. This novel procedure provides
an efficient method for the construction of Csp3–CF2 and C–O/N bonds in one step. A wide
range of functional groups are tolerated. It is proposed that a radical/SET
(single electron transfer) pathway proceeding via the fluoroalkyl
radical may be involved in the catalytic cycle.