Bacterial c-di-GMP reorganizes hematopoietic stem/progenitors and niches through STING

ChEBI2015-02-13 更新2026-07-21 收录

造血干细胞调控

STING信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-65905 数据链接链接失效反馈

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Bacterial c-di-GMP reorganizes hematopoietic stem/progenitors and niches through STING

创建时间：

2015-02-13

An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation

造血干细胞调控

细胞命运决定

The mammalian blood system is a hierarchically structured tissue. Hematopoietic stem cells (HSC) reside at the top of this hierarchy and the HSC-derived progenitor cells (HPC) have capacities for both

NIAID Data Ecosystem60

Transcriptional modifications driven by STING activation in polarizing TH1 and Th9 cells

T细胞极化机制

STING信号通路

We assessed the global transcriptional changes driven by STING activation with the cyclic dinucleotide 2'3'-cGAMP TH1 and TH9 cells polarized in vitro for 16h and 48h. Our data indicated that STING ac

NIAID Data Ecosystem60

An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation. Mus musculus

造血干细胞调控

细胞命运决定

NIAID Data Ecosystem30

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

造血干细胞调控

转录因子功能分析

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem60

In Vivo Analysis of Retroviral Enhancer Mutations in Hematopoietic Cells: SP1/EGR1 and ETS/GATA Motifs Contribute to Long Terminal Repeat Specificity

造血干细胞调控

逆转录病毒增强子功能

The objective of this work was to identify, in the context of chromosomally integrated DNA, the contribution of defined transcription factor binding motifs to the function of a complex retrovirus enha

PubMed Central40

Bacterial c-di-GMP reorganizes hematopoietic stem/progenitors and niches through STING

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