Elecsys Syphilis Signal-to-Cutoff

Supplementary file 1: Data for 19,368 syphilis screening tests on 15,764 unique patients using the Roche Diagnostics Elecsys Syphilis assay. All laboratory data involve analysis on plasma or serum. Specific data fields include: unique patient identification number (deidentified), whether result was first or only syphilis screening test performed for the specific patient within the retrospective timeframe or a repeat test (with days after initial test recorded), age in years, sex (as recorded in the electronic medical record), clinical location/unit at time of testing (emergency department, infectious disease clinic, obstetrics, inpatient, or outpatient clinic other than infectious diseases or obstetrics), syphilis screening result (negative or positive), and S/CO value for the syphilis screening. Supplementary file 2: Data for 355 positive syphilis screening tests on 270 unique patients using the Roche Diagnostics Elecsys Syphilis assay. All laboratory data involve analysis on plasma or serum. Specific data fields include: unique patient identification number (deidentified), whether result was first or only syphilis screening test performed for the specific patient within the retrospective timeframe or a repeat test, age in years, sex (as recorded in the electronic medical record), clinical location/unit at the time of syphilis testing (emergency department, infectious disease clinic, obstetrics, inpatient, or outpatient), S/CO value, results of subsequent testing in the reverse algorithm cascade (classified into the following categories: RPR reactive with specific titer noted, RPR and TP-PA non-reactive, RPR non-reactive / TP-PA inconclusive, and RPR non-reactive / TP-PA reactive), specific category (including RPR reactive results broken down into 1:1 to 1:8 and 1:16 or higher subgroups), and clinical notes.补充文件1：针对15764名唯一患者开展的19368例梅毒筛查检测数据，检测采用罗氏诊断Elecsys梅毒检测试剂盒（Roche Diagnostics Elecsys Syphilis assay）。所有实验室检测数据均针对血浆或血清样本开展分析。具体数据字段包括：已做去标识化处理的唯一患者识别编号、该患者在回顾性研究周期内的检测结果为首次/仅有的梅毒筛查检测还是重复检测（附带首次检测后的间隔天数记录）、年龄（岁）、性别（以电子病历记录为准）、检测时的临床科室/单元（包括急诊科、感染病科门诊、产科、住院部，以及除感染病科与产科外的普通门诊）、梅毒筛查结果（阴性或阳性），以及梅毒筛查的S/CO值。 补充文件2：针对270名唯一患者开展的355例梅毒筛查阳性检测数据，检测采用罗氏诊断Elecsys梅毒检测试剂盒（Roche Diagnostics Elecsys Syphilis assay）。所有实验室检测数据均针对血浆或血清样本开展分析。具体数据字段包括：已做去标识化处理的唯一患者识别编号、该患者在回顾性研究周期内的检测结果为首次/仅有的梅毒筛查检测还是重复检测、年龄（岁）、性别（以电子病历记录为准）、梅毒检测时的临床科室/单元（包括急诊科、感染病科门诊、产科、住院部及普通门诊）、S/CO值、后续逆向算法流程检测结果（分为以下类别：记录具体滴度的RPR反应阳性、RPR与TP-PA均无反应、RPR无反应/TP-PA结果不确定、RPR无反应/TP-PA反应阳性）、具体分类（其中RPR反应阳性结果进一步细分为1:1至1:8、1:16及以上两个亚组），以及临床备注信息。