Structures of picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication

The protein casein kinase 2 (CK2) has been shown to be upregulated in SARS-CoV-2 infections. However, few
inhibitors have been tested for antiviral activity against coronaviruses. In this study, highly potent and selective
bivalent inhibitors targeting the protein kinase CK2 were developed. The chemical structure of the well-known
inhibitor CX-4945 was used as an anchor for the ATP-binding site and was linked by polar and aliphatic linkers to
chemical structures that bind the cryptic αD pocket of CK2.
Here are the datasets of the structures of bivalent inhibitors described in the publication.
Related PDBs : 9QRH, 9QRI, 9QRJ, 9QSR, 9QSS, 9QSU, 9QSV