Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol

Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol Descriptor: (2~{R},3~{R},4~{S},5~{R})-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. Deposit date: 2023-07-26 Release date: 2024-04-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024人源溶酶体α-半乳糖苷酶A（human lysosomal alpha-galactosidase A）与(2R,3S,4R,5R)-2,5-双(羟甲基)吡咯烷-3,4-二醇复合物的晶体结构 描述物：(2R,3R,4S,5R)-2,5-双(羟甲基)吡咯烷-3,4-二醇、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等 作者：Li, H.Y、Huang, K.F、Ko, T.P、Cheng, W.C 沉积日期：2023-07-26 发布日期：2024-04-10 最后修改日期：2024-10-16 实验方法：X射线衍射（2.32埃） 引用文献：《双碱性亚氨基糖类作为pH选择性药理分子伴侣稳定人源α-半乳糖苷酶的机制研究》，发表于JACS Au，第4卷，2024年