five

Chikungunya virus nsP4 variant fidelity

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP477597
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The goals of this study are to understand how the chikungunya virus (CHIKV) RNA-dependent RNA polymerase, nsP4, regulates genome replication and fidelity. We generated nsP4 variants, transfected these in BHK-21 and C6/36, and 48 hours later harvest the supernatant for deep sequencing of the CHIKV genome. These studies are important to define how the polymerase functions to maintain fidelity during infection.
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2025-01-01
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