PerturBase

PerturBase is the most comprehensive database designed for the analysis and visualization of single-cell perturbation data. It curates 122 datasets from 46 publicly studies, covering 115 single-modal and 7 multi-modal datasets that include 24,254 genetic and 230 chemical perturbations from approximately 5 million cells. PerturBase, comprising the “Dataset” and “Perturbation” modules, provides insights into various analysis results, encompassing quality control, data denoising, differential gene expression analysis, functional analysis of perturbation effects, and characterization of relationships between perturbations.PerturBase是当前最为全面的单细胞扰动数据分析与可视化专用数据库。该数据库整合了来自46项公开研究的122个数据集，涵盖115个单模态（single-modal）数据集与7个多模态（multi-modal）数据集，包含约500万个细胞中的24254次遗传扰动与230次化学扰动。PerturBase设有“数据集（Dataset）”与“扰动（Perturbation）”两大模块，可支持多维度分析结果的探索与展示，涵盖质量控制、数据去噪、差异基因表达分析、扰动效应功能分析以及扰动间关联特征刻画等分析方向。

搜集汇总

背景与挑战

背景概述

PerturBase是一个专为单细胞扰动数据分析与可视化设计的综合性数据库，整合了来自46项公开研究的122个数据集，涵盖超过24,000个遗传和230个化学扰动，涉及约500万个细胞。该数据库通过'Dataset'和'Perturbation'模块提供质量控制、差异基因表达分析等多种分析结果，并以交互式网页界面支持用户浏览和可视化。