Discovery of dual GPBAR1 agonist and cysteinyl leukotriene receptor (CysLTR)1 antagonist for treating drug induced liver injury

In this research we have investigated the potential protective action of a dual GPBAR1 and CYSTLTR1 modulator in the development of hepatic inflammation and fibrosis in mice models of liver injury caused by acethaminophen (APAP) or CCL4本研究探究了一种双重GPBAR1与CYSTLTR1调节剂，在由对乙酰氨基酚（acetaminophen, APAP）或CCL4诱导的肝损伤小鼠模型中，对肝脏炎症与纤维化发展的潜在保护作用。