Relationship between baroreflex function and cerebral autoregulation during controlled breathing in healthy subjects - dataset

Funding

SONATA 18 UMO-2022/47/D/ST7/00229 National Science Centre, Poland (database 2)

SONATA-BIS UMO-2013/10/E/ST7/00117 National Science Centre, Poland (database1)

General information

Two datasets were used in this study.

The dataset 1 includes 49 healthy volunteers (28 females, 21 males, median age: 23 years, range: 18-31 years) who were measured at the Neuroengineering Laboratory at Wroclaw University of Science and Technology (WUST) between October 2014 and June 2015 (Biomedical Committee Agreement number: KB-170/2014).

The dataset  2 includes 21 healthy volunteers (14 females, 7 males, median age: 22 years, range: 18-31 years) who were prospectively measured at WUST between October 2023 and January 2024 (Biomedical Committee Agreement number: KB-179/2023/N).

Signal recordings description

ABP was measured non-invasively by a servo-controlled plethysmograph (Finometer MIDI, FMS Medical Systems, Amsterdam, The Netherlands in all subjects in dataset 1; CNAP, CNSystems Medizintechnik GmbH, Graz, Austria and Finapres Nova, FMS Medical Systems in dataset 2). The cuff was placed on the middle finger of the left hand and held at the level of the heart.

CBFV was measured in the MCA using transcranial Doppler ultrasonography (Doppler BoxX, DWL, Compumedics Germany GmbH, Singen, Germany in database 1; EMS-9PB, Delica, Shenzhen, China in database 2).

Expired end-tidal CO2 (EtCO2), carbon dioxide (CO2) concentration and respiratory rate (RR) were measured via a nasal cannula using a portable capnography monitor (RespSense™, NONIN, Plymouth, USA)

Protocol: after a resting epoch lasted at least 5 minutes, a controlled breathing session was initiated with 5-minute recordings at each of the respiratory rate: 6, 10 or 15 breaths/min (0.1 Hz, 0.17 Hz, and 0.25 Hz, respectively), guided by a digital metronome.

Data description

Type of database (database 1/database 2)

Type of device used for ABP measurement

Metadata including: sex (male M, female F), and age

Physiological parameters measured during controlled breathing, including:

 end-tidal carbon dioxide: ETCO2

Respiratory rate: RR

Carbon dioxide concentration: CO2

Heart rate: HR

Arterial blood pressure: ABP

Cerebral blood flow velocity: CBFV

Baroreflex function metrics, including:

Joint symbolical dynamics, estimated as the relative frequency of baroreflex-like word types (JSDsym) and the relative frequency of patterns that are opposed to baroreflex behaviour (JSDdiam) (Baumert et al., 2015)

Low component of Heart Rate Variability (HRV_LF; 0.04-0.15 Hz)

Baroreflex sensitivity estimated using a cross-correlation method (xBRS)

Cerebral autoregulation metrics, including TFA metrics:

coherence,

phase shift (PS)

gain

were provided for two frequency ranges: the very low-frequency range (VLF; 0.02-0.07 Hz) and the breathing frequency (BF; 0.08-0.12 Hz for 6 breaths/min; 0.15-0.19 Hz for 10 breaths/min; 0.23-0.27 Hz for 15 breaths/min). The mean values of the TFA metrics were analysed within these ranges.

Data description (new version)

Please note that in the new version of the file, baseline values (denoted as "B"), collected during sponatnaeous breathing, has been added. These values include both physiological metrcis as well as all ANS metrcis and cerebral autoregulation metrcis.

Moreover, in the new version of the file we included more ANS metrcis (HRV variabilities and entropy metrcis).