Replication Data for: Carriage and acquisition of Extended Spectrum Beta-Lactamase producing Enterobacterales among neonates admitted to hospital in Kilifi, Kenya

Infections caused by extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) among hospitalized neonates in sub-Saharan Africa pose significant clinical challenges. In a cohort study of consecutive neonatal admissions to Kilifi County Hospital (KCH) from July 2013-August 2014, we estimated ESBL-E carriage prevalence on admission using rectal swab cultures and identified risk factors using logistic regression. Swabs were collected at day 0, 2, 4 and 6 and twice-weekly follow up swabs thereafter, we estimated the incidence and identified risk factors for ESBL-E acquisition in hospital using Poisson regression. Data includes admission data for study participants, specimens collected and laboratory results and subsequent data analysis. The prevalence of ESBL-E carriage at admission was 10% (59/569). Caesarean section delivery, older neonatal age, and smaller household size were significant risk factors. Of the 510 infants admitted without ESBL-E carriage, 238 (55%) acquired carriage during their hospital stay. The incidence of acquisition was 21.4% (95% CI 19.0, 24.0) per day. The rate was positively associated with the number of known neonatal ESBL-E carriers and with the total number of neonates on the same ward.