Source Data Figure 4 .xlsx

<b>a-b</b>, Quantification of mRNA levels for collagen type II alpha 1 chain (<i>Col2a1</i>), aggrecan<i> </i>(<i>Acan</i>), SRY-box 9 (<i>Sox9</i>), proteoglycan 4 (<i>Prg4</i>), C-C motif chemokine ligand 2 (<i>Ccl2</i>), interleukin (<i>Il</i>)<i>11</i>, <i>Il6</i>, ADAM metallopeptidase with thrombospondin type 1 motif (<i>Adamts</i>)<i>1</i>, <i>Adamts5</i>, matrix metalloproteinase (<i>Mmp</i>)<i>3,</i> and <i>Mmp13</i> in articular cartilage obtained from sham, vehicle, and BNTA-treated (1.5 mg kg^-1) rats at 4 w and 8 w (a, <i>Col2a1</i>, <i>Acan,</i> <i>Sox9</i>, <i>Prg4, Adamts5</i>,<i> Ccl2</i>, <i>Il11</i>, <i>Il6</i>,<i> </i>and<i> Mmp3, </i>one-way ANOVA; <i>Adamts1</i> and <i>Mmp13, </i>nonparametric test; b, <i>Acan</i>, <i>Sox9</i>, <i>Prg4</i>, <i>Il11</i>, and <i>Mmp13, </i>one-way ANOVA; <i>Col2a1</i>, <i>Ccl2, Il6</i>, <i>Adamts1</i>, <i>Adamts5,</i> and <i>Mmp3, </i>nonparametric test; n = 5 for each group). <b>c</b>, Biomechanical properties of cartilage samples from sham, vehicle, and BNTA-treated (1.5 mg kg^-1) rats at 4 w assessed using a nanoindentation test (n = 6 for each group; elastic modulus, one-way ANOVA; hardness, nonparametric test).<b> f</b>, Quantitative micro-CT analysis of tibial subchondral bone with trabecular bone volume per total volume (BV/TV; unpaired two-tailed Student’s <i>t</i>-test; n = 4 for each group) and trabecular bone pattern factor (Tb. Pf; unpaired two-tailed Student’s <i>t</i>-test; n = 4 for each group) in the vehicle and BNTA (1.5 mg kg^-1) groups at 4 w and 8 w. Each data point represents one individual rat. All data are shown as the mean ± standard deviation (s. d.). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001.