Supplemental files for: A consensus view of the proteome of the last universal common ancestor

The availability of genomic and proteomic data from across the tree of life has made it possible to infer features of the genome and proteome of the last universal common ancestor of life (LUCA). A number of studies have done so, all using a unique set of methods and bioinformatics databases. Here, we compare predictions across eight such studies and measure both their agreement with one another and with the consensus predictions among them. We find that some LUCA genome studies show a strong agreement with the consensus predictions of the others, but that no individual study shares a high or even moderate degree of similarity with any other individual study. From these observations, we conclude that the consensus among studies provides a more accurate depiction of the proteome of the LUCA and its functional repertoire. The set of consensus LUCA protein family predictions between all of these studies portrays a LUCA genome that, at minimum, encoded functions related to protein synthesis...覆盖生命之树各分支的基因组与蛋白质组数据的公开可得，使得推断生命最后通用共同祖先（Last Universal Common Ancestor, LUCA）的基因组与蛋白质组特征成为可能。已有多项研究开展了此类推断，且均采用了一套独特的方法与生物信息学数据库。本研究对八项此类研究的预测结果进行了对比，并同时评估了各项预测间的一致性，以及各项预测与研究群体共识预测的契合程度。研究发现，部分LUCA基因组研究与其他研究的共识预测结果具有较高一致性，但任意两项独立研究之间的相似性均未达到较高甚至中等水平。基于上述观察，我们得出结论：多项研究间的共识能够更为准确地刻画LUCA的蛋白质组及其功能谱。所有这些研究得出的LUCA蛋白质家族共识预测结果，勾勒出了一个至少编码了蛋白质合成相关功能的LUCA基因组……