PTEN locus 3D genome analysis datasets in human blood and breast cell lines (bedpe and matrix formats)

This Zenodo deposit contains Hi-C and Tiled-C matrixes, and Tiled-C chromatin interaction data from multiple human cell lines: ## Contents *.matrix: Iced dense interaction matrices at 2kb or 10kb resolution *.bed: Genomic bin definitions used for matrix construction (2 kb or 10kb resolution). *.bedpe: BEDPE-format files representing paired-end contacts for each tiled region ## Tiled-C Processing note The contact matrices and bedpe file provided here are the result of merging replicate Tiled-C experiments per cell line. Each `.matrix` file thus reflects pooled chromatin interaction profiles across replicates. ## Hi-C Experimental context - Technique: Hi-C - Pipeline : HiC-Pro- Resolution: 2kb and 10kb- Cell lines: GM12878, and MDA-MB-231- Species: Homo sapiens (hg38) ## Tiled-C Experimental context - Technique: Tiled-C (targeted chromosome conformation capture) - Target locus: 3Mb centered on PTEN locus (chr10) - Pipeline : HiC-Pro- Resolution: 2 kb- Cell lines: GM12878, K562, RMwt, RFmut, MDA-MB-231, MDA-MB-453, MDA-MB-468, MDA-MB-436, HCC-1937, MCF 10A and MCF 10A PTEN-/-- Species: Homo sapiens (hg38) For more details, see the Methods section of the accompanying manuscript. ## Citation Please cite this dataset using the DOI provided by Zenodo. ## Contact For questions, please contact the corresponding author of the associated manuscript.