Quantitative Serum Proteomic Study Reveals that Fibrinogen-Related Proteins May Participate in the Pathophysiological Process of Simple Febrile Convulsion

Simple
febrile convulsion (SFC) is a common disease that is mainly
caused by fever from extracranial infections. In this study, we used
proteomic approaches involving discovery and validation cohorts to
examine the proteomes of serum from children who were diagnosed with
SFC, children with fever but without convulsion, and healthy children
(normal controls). We identified 86 proteins involved in different
biological pathways that were significantly different between the
SFC and normal control groups. Of these 86 proteins, 35 had higher
expression in the SFC group compared with the normal control group,
whereas 51 had lower expression. Notably, fibrinogen-related proteins
involved in the coagulation system pathway were markedly decreased
in the SFC group. Targeted and absolute quantification of fibrinogen-related
proteins was performed and validated the potential of these proteins
as biomarkers. Thus, fibrinogen-related proteins may participate in
the pathophysiological process of SFC and may be potential biomarkers
for the diagnosis of SFC.