EDA:EDAR binds EDARADD

Ectodysplasin-A (EDA) is a trimeric type II membrane protein related to the tumor necrosis factor (TNF)-related ligand family. Activation of the NF-kappaB pathway by the tumor necrosis factor receptor superfamily member EDAR (EDAR) and its downstream adaptator EDAR-associated death domain (EDARADD) is essential for the development and regulation of hair follicles, teeth, exocrine glands and other ectodermal structures (Yan et al. 2002). EDA isoform 1 specifically binds EDAR. A small number of hypohidrotic ectodermal dysplasias (HEDs) are caused by mutations in EDARADD (Chassaing et al. 2010).

Ectodysplasin-A（表皮发育不全素A）是一种与肿瘤坏死因子（TNF）相关配体家族相关的三聚体II型膜蛋白。肿瘤坏死因子受体超家族成员EDAR（EDAR）及其下游适配器EDAR关联死亡域（EDARADD）激活NF-kappaB通路对于毛囊、牙齿、外分泌腺以及其他表皮结构的发育和调控至关重要（Yan等，2002年）。EDA亚型1特异性结合EDAR。少数少汗性表皮发育不良（HEDs）由EDARADD基因突变引起（Chassaing等，2010年）。