Backcross of Inbred Suncus for Elucidating the Genetic Mechanism in Postoperative Nausea and Vomiting

Postoperative nausea and vomiting (PONV) is a serious complication after emergence from general anesthesia. However, the molecular mechanisms underlying PONV have not been fully elucidated. Musk shrews are used for emetic research worldwide because standard laboratory animals, such as rats and mice, are not capable of vomiting. The aims of this study were to determine changes in gene expression in the shrew brainstem and to try to determine the causative genes for PONV.