Data from: Volunteer motivators for participating in HIV vaccine clinical trials in Nairobi, Kenya

Article Authors Metrics Comments Related Content Abstract Introduction Materials and methods Results Discussion Limitations Conclusion Supporting information Acknowledgments References Reader Comments (0) Media Coverage (0) Figures Abstract Background: 1.5 million Kenyans are living with HIV/AIDS as per 2015 estimates. Though there is a notable decline in new HIV infections, continued effort is still needed to develop an efficacious, accessible and affordable HIV vaccine. HIV vaccine clinical trials bear risks, hence a need to understand volunteer motivators for enrolment, retention and follow-up. Understanding the factors that motivate volunteers to participate in a clinical trial can help to strategize, refine targeting and thus increase enrolment of volunteers in future HIV vaccine clinical trials. The health belief model classifies motivators into social benefits such as ‘advancing research’ and collaboration with science, and personal benefits such as health benefits and financial interests. Method: A thematic analysis was carried out on data obtained from four HIV clinical trials conducted at KAVI-Institute of Clinical Research in Nairobi Kenya from 2009 to 2015. Responses were obtained from a Questionnaire administered to the volunteers during their screening visit at the research site. Results: Of the 281 healthy, HIV-uninfected volunteers participating in this study; 38% were motivated by personal benefits including, 31% motivated by health benefits and 7% motivated by possible financial gains. In addition, 62% of the volunteers were motivated by social benefits with 20% of who were seeking to help their family/society/world while 42% were interested in advancing research. Conclusion: The majority of volunteers in the HIV vaccine trials at our site were motivated by social benefits, suggesting that altruism can be a major contributor to participation in HIV vaccine studies. Personal benefits were a secondary motivator for the volunteers. The motivators to volunteer in HIV clinical trials were similar across ages, education level and gender. Education on what is needed (including volunteer participation) to develop an efficacious vaccine could be the key to greater volunteer motivation to participate in HIV vaccine clinical trials.文章 作者 研究指标 评论 相关内容 摘要 引言 材料与方法 结果 讨论 局限性 结论 支持信息 致谢 参考文献 读者评论（0） 媒体报道（0） 图表 摘要 背景：根据2015年的统计估算，肯尼亚共有150万艾滋病病毒/艾滋病（HIV/AIDS）感染者。尽管新增HIV感染病例已出现显著下降，但仍需持续发力，研发安全有效、可及性强且价格可负担的HIV疫苗。HIV疫苗临床试验存在一定风险，因此亟需了解志愿者参与试验、留存及后续随访的动机因素。明晰激励志愿者参与临床试验的相关因素，有助于制定策略、优化招募靶向，进而提升未来HIV疫苗临床试验的志愿者招募率。健康信念模型（Health Belief Model）将动机划分为两类：一类是社会收益，例如"推动科研进展"以及参与科学合作；另一类则是个人收益，包括健康获益与经济利益。 方法：本研究对2009年至2015年间，在肯尼亚内罗毕KAVI临床研究所（KAVI-Institute of Clinical Research）开展的四项HIV临床试验所获数据开展了主题分析。数据来源于研究现场筛查访视时向志愿者发放的调查问卷回复。 结果：本研究共纳入281名健康、HIV阴性的志愿者。其中38%的志愿者受个人收益驱动，具体而言，31%的志愿者因健康获益参与试验，7%的志愿者则是为了潜在的经济回报。此外，62%的志愿者受社会收益驱动：其中20%的志愿者旨在帮助家人、社会或全球社区，42%的志愿者希望推动科研进展。 结论：本研究所在机构开展的HIV疫苗临床试验中，绝大多数志愿者均受社会收益驱动，这表明利他主义是推动志愿者参与HIV疫苗研究的核心因素之一。个人收益仅为次要驱动因素。不同年龄、受教育程度及性别的志愿者，其参与试验的动机并无显著差异。加强关于研发有效HIV疫苗所需工作（包括志愿者参与）的科普教育，或可成为提升HIV疫苗临床试验志愿者参与积极性的关键举措。