Possible molecular mechanisms for the roles of microRNA-21 played in lung cancer

we aimed to find the possible molecular mechanisms for the roles of microRNA-21(miRNA-21) played in lung cancer.MiRNA21-5p inhibitor was transfected into A549 cells. Then, RNA was extracted and RT-PCR was conducted. After obtaining good results, mRNA sequencing was performed. We find that miRNA-21 may play significant roles in lung cancer partly via MCM10 and CDCA8. Furthermore, miRNA-21 targeted CDCA8 and then played roles in lung cancer via the process of cell division. Tfdp3 and RAD21 are important TFs in miRNA-21 interfered lung cancer.