Structure of human Smoothened in complex with cholesterol and SAG
收藏Protein Data Bank Japan2024-10-23 更新2026-04-19 收录
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Structure of human Smoothened in complex with cholesterol and SAG Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ... Authors: Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C. Deposit date: 2022-04-07 Release date: 2022-06-15 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3 Å) Cite: Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Sci Adv, 8, 2022
与胆固醇及Smoothened激动剂（SAG）结合的人源平滑蛋白（Smoothened）结构
配体描述：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、3-氯-N-[反式-4-(甲氨基)环己基]-N-{[3-(吡啶-4-基)苯基]甲基}-1-苯并噻吩-2-甲酰胺、胆固醇等
作者：Byrne, E.F.X、Woolley, R.E、Ansell, B、Sansom, M.S.P、Newstead, S、Siebold, C
提交日期：2022-04-07
发布日期：2022-06-15
最后修改日期：2024-10-23
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率为3埃
引用文献：Patched 1通过调控甾醇与其细胞外半胱氨酸富集结构域的结合来调控Smoothened。《科学进展》（Science Advances），8卷，2022年
创建时间：
2022-04-07
