Patient-Derived Models of Prostate Cancer for Personalized Medicine. Patient-Derived Models of Prostate Cancer for Personalized Medicine

The aim of this study was to develop a molecular dataset that reflects the heterogeneity of prostate cancer using patient-derived xenografts (PDX) grown in the subcutaneous flank of SCID (CB17/Icr-Prkdcscid/IcrIcoCrl) mice. Whole-genome, targeted sequencing, and RNA sequencing were performed on tumors from 44 PDXs derived from 38 patients. The cohort included models derived from different morphologic groups, disease states, and organ sites (including circulating tumor cells). Paired samples from the same patient tumor and longitudinal samples were included to study heterogeneity and treatment effects, respectively.