Quantitative sensory testing dataset with capsaicin and menthol sensitization assessing modality-specific sex differences and sensitization effect sizes in 125 healthy volunteers

This dataset contains experimental pain threshold measurements and classical pain model data collected from 125 healthy adult volunteers under both baseline and chemically-sensitized conditions. The data were generated using established quantitative sensory testing (QST) protocols, including mechanical (punctate and blunt pressure), thermal (heat and cold), and electrical pain modalities. Sensitization was induced using topical capsaicin (for heat and punctate pressure) and menthol (for cold) to assess pain plasticity and sensitization mechanisms. Each file provides pain threshold profiles, including raw measurements, transformed values for machine learning applications, and comprehensive participant metadata. File overview: File 1: exp_pain_data_orig.csv This file contains the original pain threshold data matrix with 125 rows (subjects) and 9 columns (variables). The first column ("ID") lists arbitrary subject identifiers. Columns 2 through 9 include pain threshold measurements from classical experimental pain models: vonFrey (punctate pressure, log gram von Frey), Heat (thermal, °C), Cold (thermal, °C), Pressure (blunt mechanical, N/m²), Current (electrical, mA), and their sensitized counterparts vonFrey_Capsaicin, Heat_Capsaicin, and Cold_Menthol. Values represent the stimulus intensity at which participants first reported pain, with some measurements reaching technical device limits. File 2: exp_pain_data_transformed.csv This file contains the same 125 subjects with 12 columns of transformed pain threshold data prepared for machine learning analyses. It includes eight transformed pain threshold variables (Heat, Pressure, Current, Heat_Capsaicin, Cold, Cold_Menthol, vonFrey, vonFrey_Capsaicin) and three calculated sensitization effect variables (Capsaicin_Effect_Heat, Menthol_Effect_Cold, Capsaicin_Effect_vonFrey). Transformations include signed logarithmic transformation (sign(x) × log(|x| + 1)) applied to all measurements, conditional linear multiple imputation for censored data (left-censored cold thresholds at 0°C, right-censored von Frey thresholds at log(301) mN), and z-score standardization. Sensitization effects were computed as differences between baseline and sensitized log-transformed thresholds. File 3: exp_pain_metadata.csv This metadata file includes 125 subjects with six columns. The first column lists subject IDs consistent with files 1 and 2. The second column provides age in years. Column 3 indicates smoking status ("Smoker" or "Nonsmoker"). Column 4 provides biological sex ("Female" or "Male"). Column 5 indicates the experimenter who conducted the measurements ("F" for female tester, "M" for male tester). Column 6 ("TrainingValidation") indicates assignment to training or validation sets, determined through optimal distribution-preserving downsampling (80% training, 20% validation). All data are anonymized and formatted for reproducibility and secondary analysis.本数据集包含从125名健康成年志愿者处采集的实验性痛阈测量数据与经典疼痛模型数据，采集场景涵盖基线状态与化学致敏两种状态。所有数据均采用成熟的定量感觉测试（quantitative sensory testing, QST）方案生成，测试模态包括机械刺激（点状压力与钝性压力）、温度觉刺激（热刺激与冷刺激）以及电刺激痛觉。致敏处理分别通过外用辣椒素（用于热刺激与点状压力测试）与薄荷醇（用于冷刺激测试）实现，用以评估疼痛可塑性与致敏机制。每个文件均包含痛阈特征数据，包括原始测量值、适配机器学习应用的转换值，以及完整的受试者元数据。 文件概述： 文件1: exp_pain_data_orig.csv 该文件包含原始痛阈数据矩阵，共125行（对应受试者）与9列（对应变量）。第一列（"ID"）为任意受试者标识符。第2至9列为经典实验疼痛模型的痛阈测量值：冯·弗雷（von Frey，点状压力，单位为对数克数）、热刺激（温度觉，单位为摄氏度）、冷刺激（温度觉，单位为摄氏度）、压力（钝性机械刺激，单位为牛每平方米）、电流（电刺激，单位为毫安），以及对应的致敏后测量值：vonFrey_Capsaicin、Heat_Capsaicin与Cold_Menthol。数值代表受试者首次报告疼痛时的刺激强度，部分测量值已达到实验设备的技术极限。 文件2: exp_pain_data_transformed.csv 该文件包含同125名受试者的12列转换后痛阈数据，专为机器学习分析准备。其中包含8项转换后的痛阈变量：Heat、Pressure、Current、Heat_Capsaicin、Cold、Cold_Menthol、vonFrey、vonFrey_Capsaicin，以及3项计算得到的致敏效应变量：Capsaicin_Effect_Heat、Menthol_Effect_Cold与Capsaicin_Effect_vonFrey。数据转换方式包括：对所有测量值应用符号对数变换（sign(x) × log(|x| + 1)）、针对截尾数据的条件线性多重插补（左截尾冷刺激阈值为0℃，右截尾von Frey阈值为log(301)毫牛），以及z分数标准化。致敏效应通过基线与致敏后对数转换阈值的差值计算得到。 文件3: exp_pain_metadata.csv 该元数据文件包含125名受试者的6项信息。第一列为与文件1、2一致的受试者ID。第二列为受试者年龄（单位：岁）。第三列为吸烟状态（"Smoker"即吸烟者，"Nonsmoker"即非吸烟者）。第四列为生物学性别（"Female"即女性，"Male"即男性）。第五列为执行测量的实验人员信息（"F"代表女性测试者，"M"代表男性测试者）。第六列（"TrainingValidation"）表示受试者被分配至训练集或验证集，分配方式采用最优分布保持下采样（80%为训练集，20%为验证集）。 所有数据均已匿名化，格式适配可复现性研究与二次分析。