Bile Acids Are Endogenous Antagonists For the Leukemia inhibitory factor (LIF) receptor

The leukemia inhibitory factor (LIF) receptor is involved in various cellular processes, including gastrointestinal cancer growth and invasiveness. Secondary bile acids such as DCA, LCA and its derivatives were found to inhibit LIF/LIFR complex formation, and STAT3 phosphorylation.白血病抑制因子（LIF）受体参与多种细胞过程，包括胃肠道肿瘤的生长与侵袭性。研究发现，DCA、LCA及其衍生物等次级胆汁酸可抑制LIF/LIFR复合物的形成以及信号转导与转录激活因子3（STAT3）的磷酸化。