Leydig Cells in Spermatogenesis-Deficient Testes Experience Stress, but Proliferate to Enhance Testosterone Synthesis II

We investigated somatic cell dynamics in testicular tissue lacking spermatogenesis using model mice with testis-specific deletion of the histone H3 variant gene H3t. Leydig cells in testes lacking spermatogenesis led to increased testosterone synthesis that occurred alongside a high inflammatory response and oxidative stress.本研究通过构建组蛋白H3变体基因H3t睾丸特异性敲除的模型小鼠，对精子发生缺失的睾丸组织中的体细胞动态变化展开了研究。此类精子发生缺失的睾丸中的莱迪希细胞（Leydig cells）可增强睾酮合成能力，且该过程伴随显著的炎症反应与氧化应激。