Ago1 controls myogenic differentiation by regulating eRNA mediated CBP guided epigenome reprogramming
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资源简介：
The role of Argonaute (Ago) proteins in post-transcriptional gene silencing in the cytoplasm is well characterized. However, its nuclear function still remains elusive. In this work, we investigated the function of nuclear Ago1 in gene expression regulation during muscle differentiation. Ago1 is enriched at enhancer regions of myogenic genes and loss of Ago1 inhibits activation of myogenic program. Ago1 depletion leads to loss of eRNA-CBP interaction with consequent global impairment of CBP acetyltransferase activity and failure of MyoD mediated activation of myogenic cell differentiation .
创建时间：
2021-11-20
