Nine-Locus HLA Allele and Haplotype Frequency Estimates in US Populations from NMDP donors

Volunteer donor data from the NMDP registry provide a deep sampling of HLA from US populations and allows for characterization of the complex landscape of HLA haplotype diversity for the classical HLA Class I (A, B, C) and Class II (DRB1, DRB3/4/5, DQA1, DQB1, DPA1, DPB1) loci. Here we present nine-locus classical HLA allele and haplotype frequency estimates for five broad and 21 detailed US populations based on approximately ten million samples with targeted genotyping by DNA-based methods. Advancements in next-generation sequencing provide extensive HLA genotyping, offering new insights into the haplotype structure and diversity of the MHC complex, expanding knowledge, especially for Class II haplotypes.