Pharmacokinetics parameters obtained from animals injected with a single dose of ceftiofur and PLGA-cef.

Note: Data represent the mean ± standard deviation of serum values in rats (n = 3 per group) injected with free ceftiofur (700 μg/kg of weight), and PLGA-cef microparticles (10 mg/kg of weight). Parameters: Cmax, maximal concentration; Tmax, time to maximal concentration; t1/2, elimination half-life; AUC, area under curve; α, constant of absorption; β, constant of elimination; A, rate constant representing slope of distribution; B, rate constant representing slope of elimination phase. *Values with statistically significant differences (P<0.05, Mann–Whitney). Pharmacokinetics parameters obtained from animals injected with a single dose of ceftiofur and PLGA-cef.