Crystal Structure of H. influenzae TrmD in complex with Compound 27

Crystal Structure of H. influenzae TrmD in complex with Compound 27 Descriptor: 1-[[4-(aminomethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-5-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase Authors: Hall, G, Cowan, R, Carr, M.D. Deposit date: 2022-08-10 Release date: 2023-06-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90, 2023流感嗜血杆菌（Haemophilus influenzae, H. influenzae）TrmD与化合物27的共晶晶体结构 描述项：1-[[4-(氨基甲基)苯基]甲基]吡咯并[2,3-b]吡啶-5-甲酰胺、柠檬酸、转运RNA（tRNA）(鸟嘌呤-N(1)-)-甲基转移酶 作者：G·霍尔、R·考恩、M·D·卡尔 存档日期：2022-08-10 发布日期：2023-06-14 最后修改日期：2024-02-07 实验方法：X射线衍射（2.4埃） 引用文献：通过设计一系列强效TrmD抑制剂并开展微生物学表征，评估TrmD作为潜在抗菌靶点的成药性。Bioorg.Med.Chem.Lett., 90, 2023