Expression pattern of Pseudomonas aeruginosa biofilm-residing bacteria exposed to gentamicin or surface acoustic waves or gentamicin and surface acoustic waves combined

Bacteria are known to respond to various environmental stimuli including nutrient deprivation, osmotic stress, and exposure to antibiotics. Our experimental data showed that P. aeruginosa biofilm formed in urinary catheters is very suseptible to gentamicin treatment when combined with exposure to surface acoustic waves Our goal was to establish whether P. aeruginosa is capable of specifically sensing the surface acoustic waves as well as to try and decipher the molecular mechanism underlying the increased biofilm suseptibility to antibiotics treatment To fully assess the bacterial response we subjected the P. aeruginosa biofilm to four different treatments: control (no treatment); gentamicin treatment alone; surface acoustic waves treatment alone and combined treatment of gentamicin with surface acoustic waves.