Azomethine Ylide Cycloaddition Approach toward Dendrobine: Synthesis of 5‑Deoxymubironine C
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https://figshare.com/articles/dataset/Azomethine_Ylide_Cycloaddition_Approach_toward_Dendrobine_Synthesis_of_5_Deoxymubironine_C/5952541
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资源简介：
A concise route to the azatricyclo[6.2.1.04,11]undecane
core of (−)-dendrobine and (−)-mubironine C is described
wherein an unstabilized azomethine ylide cycloaddition provides the
complete carbon framework of the natural products. The cyclization
precursor is made in short order from (R)-carvone
through an unconventional high-pressure Ireland–Claisen reaction.
Attempts to install a final hydroxyl group through an intramolecular
lactonization strategy and the observation of an unexpected and highly
complex enal–ene product are also reported.
创建时间：
2018-03-06
