Occupational Contact Dermatitis: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001 to 2016

Provide an overview of occupational skin disease (OSD) and analysis of occupational ACD in North American patients undergoing patch-testing 2001-2016. Methods: Patients with OSD were analyzed for frequency of allergic reactions to a screening series of allergens, occupational relevance, location of skin disease, and exposure sources. Demographic and occupation/industry information was recorded. Results: Of 38,614 patients evaluated, 4471 (11.6%) had OSD, of whom 3150 (70.5%) had ACD. The most common occupationally related allergens included rubber accelerators, preservatives and bisphenol A epoxy resin. Hands (75.8%), arms (30.0%) and face (15.9%) were common sites of dermatitis.. The most affected occupations were service workers and machine operators. Limitations: Our cohort may not reflect the general working population. Conclusion: This study identified common occupational allergens, exposure sources, and occupations/industries at risk. This information may help the clinician evaluate and manage patients with occupational contact dermatitis本研究旨在概述职业性皮肤病（occupational skin disease, OSD），并分析2001至2016年北美接受斑贴试验（patch-testing）的患者中的职业性变应性接触性皮炎（occupational allergic contact dermatitis, ACD）病例情况。 方法：对确诊职业性皮肤病的患者，分析其对标准化筛查变应原组的过敏反应发生率、职业相关性、皮损部位及暴露来源，并记录患者的人口学特征与职业、行业信息。 结果：本研究共评估38614例患者，其中4471例（11.6%）罹患职业性皮肤病；该群体内3150例（70.5%）合并变应性接触性皮炎。最常见的职业相关变应原包括橡胶促进剂（rubber accelerators）、防腐剂（preservatives）与双酚A环氧树脂（bisphenol A epoxy resin）。皮炎好发部位依次为手部（75.8%）、手臂（30.0%）与面部（15.9%）。受累最显著的职业类别为服务行业从业者与机械操作人员。 局限性：本研究队列无法代表一般劳动人群。 结论：本研究明确了常见职业性变应原、暴露来源及高风险职业与行业。上述结果可为临床医师评估与管理职业性接触性皮炎患者提供参考依据。