Effects of individualized step targets on physical activity in COPD. A randomized study

Purpose: Improving physical activity (PA) is important in patients with chronic obstructive pulmonary disease (COPD). Goal setting can be a possible intervention, but its effect cannot be maintained for six months. We evaluated the effects of providing an individualized target step count, reflecting the disease condition of each patient, on PA and other factors, such as myokines, after six months in patients with COPD.
Patients and methods: We performed a randomized parallel group, open-label study (INTAR-Step study) between the target provision (intervention) group and the usual care (control) group and investigated differences in the proportion of subjects who achieved the target as a primary endpoint and differences in changes in PA parameters and myokines as secondary endpoints. This study was registered with UMIN-CTR (UMIN000046390, January 13, 2022).
Results: A total of 73 patients were analyzed (intervention, n=38; control, n=35). The proportion of participants in the interventio..., Recruitment was performed at five institutes, namely Osaka Metropolitan University, Saga University, Yamaguchi University, Wakayama Medical University, and NHO Wakayama Hospital, from June 2022 to January 2023. Written informed consent was obtained from all participants. This study was approved by the ethics committee of NHO Wakayama Hospital (approval number: 03-06; approval date: October 26, 2021) and registered with UMIN-CTR (UMIN000046390, January 13, 2022)., , # Effects of individualized step targets on physical activity in COPD. A randomized study

[https://doi.org/10.5061/dryad.v41ns1s6c](https://doi.org/10.5061/dryad.v41ns1s6c)

## Description of the data and file structure

After obtaining informed consent (visit 1), participants were required to measure patient demographics, post-bronchodilator spirometry, patient-reported outcome measures (PROs), serum myokines, body composition, chest computed tomography (CT), transdermal advanced glycation end-products (AGEs), and PA using an accelerometer with a recording of a diary for 2 weeks (Data6_visit2.csv). Between four and twenty weeks after visit 1, participants were randomly assigned to the intervention or the control group (visit 2; week 0). Subjects in the intervention group were educated and encouraged to increase their step counts and were provided with the target step count value and a pedometer, whereas subjects in the control group were educated and encouraged to increase their step...,