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Data corresponding to the manuscript submitted: Insulin effects on honeybee appetitive behaviour
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2016-05-20
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Selected compounds which alter insulin secretion in acute (hours) and chronic (days) exposure scenario's.
Reported effects on basal (BIS) and glucose stimulated (GSIS) insulin secretion, and the primary targets via which the compounds exert their effects are given, together with the expected control funct
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Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets
Complex diseases result from molecular changes induced by multiple genetic factors and the environment. To derive a systems view of how genetic loci interact in the context of tissue-specific molecula
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Inhibition of MGL reduced GSIS in INS-1 cells and isolated rat islets.
(A) JZL184 dose-dependently reduced GSIS during static incubations in INS-1 cells (n = 3). (B) JZL184 (10 μM) reduced GSIS in INS-1 cells regardless of the temporal exposure (n = 3). (C) INS-1 cells d
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The Transcriptional Co-Regulator HCF-1 Is Required for INS-1 β-cell Glucose-Stimulated Insulin Secretion
The transcriptional co-regulator host cell factor-1 (HCF-1) plays critical roles in promoting cell cycle progression in diverse cell types, and in maintaining self-renewal of embryonic stem cells, but
Figshare2016-01-18 更新40
The effect of TRPM7 kinase inactivation on expression levels of the genes involved in insulin production and cell cycle regulation in pancreatic islets. The effect of TRPM7 kinase inactivation on expression levels of the genes involved in insulin production and cell cycle regulation in pancreatic islets
To investigate the function of TRPM7 kinase in the regulation of insulin production and beta cell proliferation, we used a mouse model harboring a single point mutation at the active site of the enzym
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